MRI safe micro endoscope system with integrated ultrasonic function
Population ageing is a challenge for the future of healthcare systems. Often, an elderly individual may suffer from more than one disease or medical condition, while the diagnostic and therapeutic techniques for one may be incompatible with those of the others. The fact that more people with multiple chronic conditions will require health services clearly demands for compatibility of therapy and diagnosis. On the other hand, active devices can offer new and effective solutions for heath check and treatment. Therefore, many patients will be wearing such implants in their bodies for short or lifetime periods. These devices are not always compatible with the key diagnostic tools, one of them being Magnetic Resonance Imaging (MRI), a very accurate disease detection technique.

Finding a solution for this situation will not only help patients to benefit from a broader range of medical advancements, but also contribute to the development of more effective “combined” therapeutic and diagnostic techniques.

As a step in this direction we have developed a MRI safe endoscopic probe demonstrator for brain surgery. The so-called “μendoscope” integrates ultrasonic and optic components into a single device for use in intraoperative procedures.

The optical functionality (light and image fibers) is used to guide the μendoscope’s tip and locate the tumour tissue. Once temporarily implanted, the μendoscope is fixed in the desired position for the duration of examination. Ultrasound functionality of the μendoscope is then employed to obtain high resolution and depth scans of the target and identify tiny areas of the brain tissue. This approach also allows for a therapeutic application of the μendoscope, so that by delivering the sufficient acoustic energy the tumour cell destruction can be achieved. The diameter of the current probe is 5 mm. Further miniaturization will enable positioning the tip much closer to the affected tissue and detect much smaller lesions.

As MR safety considerations have been taken into account in the design and operation procedure of the μendoscope, MRI could be performed while the μendoscope is inserted into the brain. This way, these two powerful modalities complement each other and increase the accuracy of diagnosis and therapy. The µendoscope is developed by the German partners  PolyDiagnost GmbH, Fraunhofer ENAS und MR:Comp GmbH within the ENIAC Joint Undertaking (JU) DENECOR.

Fully-integrated Lab-on-Chip Systems for Point-of-Care diagnostics, health monitoring, infectious diseases, environmental monitoring and veterinary diagnostics
Point-of-Need analytical systems enable the complex chemical and bio-chemical analytical procedures without the need for highly specialized laboratory equipment or staff. The presented chipcard-sized systems contain various functions: integrated microfluidic pumps, heaters, PCR, bio sensors and reagents.
This portfolio enables the integration and miniaturization of nearly every assay in cost optimized disposable systems. Presented applications include immunoassays (various types), tropical and other infectious diseases, antibiotic resistance testing by SNP (single nucleotide polymorphism) detection, and biosensor and assay test platforms. From the project VIP SERON the integration of a novel highly sensitive SERS-biosensor, which is freshly generated for every measurement, will be presented.


The Fraunhofer researches talk about the following topics at the COMPAMED HIGH-TECH FORUM by IVAM in hall 8A:

Smart Sensor Solution Day
November 17, 2015 (11:40-12:00 a.m.)
Maik-Julian Büker, Fraunhofer ENAS
Wireless Active Implants

Smart Sensor Solution Day
November 17, 2015 (2:30-2:50 p.m.)
Dr. Mario Baum, Fraunhofer ENAS
Biocompatible Thin Film Encapsulation

Brazilian Session
November 18, 2015 (3:15-3:45 p.m.)
Dr. Jörg Nestler, BiFlow Systems GmbH / Andreas Morschhauser, Fraunhofer ENAS
Point-of-Care Diagnostics for Tropical Diseases (PodiTrodi): Lab-on-a-Chip Development for Chagas‘ Disease in a Joint European-Brazilian Project