Cutting-Edge Technologies for Advanced, Ultra-Precise Ultrasound: Razor-Sharp Insight for Medicine and Industry

Imaging methods such as ultrasound and photoacoustics are integral components of the testing procedures used in medicine and industry today. They make it possible to visualize internal structures – from organic tissue to materials – non-invasively, without damaging or even touching them. As the key to further diagnosis, state-of-the-art methods can be used to identify even the tiniest changes and abnormalities in organs, muscles or blood vessels in real time, detect serious disease early on and initiate precision-targeted therapeutic measures. But that is not all; ultrasound methods are also used across a host of industrial applications for nondestructive testing, inspection and analysis to reveal defects and assure the quality of components. With their ultrasonic transducers, researchers from Fraunhofer ENAS are helping to unlock fascinating insights into the inside of the human body and thus improve healthcare. At the same time, they are also making it possible to trace even hidden details of technological components, enhancing safety and reliability.

Ultrasound examinations are among the most important imaging methods in the modern world today. Also known as sonography, ultrasound is used as a quick, pain-free way to gather diagnostic information pointing to serious disease or to monitor the progress of certain health conditions. Ultrasound is also helpful in industrial applications as a reliable and nondestructive way to test aspects such as material properties or detect irregularities and flaws in materials.

 

From echo to image: ultrasound as a window on the body in medicine

“In sonography, an ultrasonic probe is moved over the patient’s skin, in contact with the area of the body that is undergoing the scan. Electrical signals generate sound waves that penetrate deep into the body through the probe. When these waves make contact with organs or tissue, some fraction bounces back, so it is reflected like an echo. But since bones, muscles and blood vessels have different properties and structures, they vary widely in how they reflect or absorb the sound waves,” says Dr. Chris Stöckel, head of the “MEMS/NEMS Technologies” group at Fraunhofer ENAS, explaining how ultrasound works.

For example, bones are highly reflective, but ultrasonic waves pass through liquids such as blood. They do not reflect sound waves but absorb them instead. Based on these different levels of reflection and absorption, electrical impulses are generated and then used to calculate the typical black-and-white ultrasound image. Heavily reflective areas show up in white, while absorptive types of tissue are visualized in black. The 2D image of the organ or tissue scanned in this way gives doctors information about the health of that area of the body and indications of any anomalies.

 

Tiny technology, big impact: Micromachined ultrasonic transducers reveal delicate structures in medical diagnostics

Cutting-edge high-resolution technologies are needed in order to detect even the tiniest irregularities inside the body. The researchers at Fraunhofer ENAS are working to develop one such technology. Built into ultrasonic probes, micromachined ultrasonic transducers (MUTs) from the scientists in Chemnitz allow for detection of even the finest structures.

“This is made possible by ultra-thin membranes produced on silicon wafers that are built into the inside of the ultrasonic transducer. At just one to five micrometers in thickness, they’re smaller than a red blood cell, for example. Applying an electric current starts these membranes vibrating, which creates high-frequency sound waves inaudible to the human ear. When those sound waves make contact with an object such as tissue, the signal is reflected and can be analyzed,” explains Dr. Nooshin Saeidi, head of the “Micro Acoustic Systems” group at Fraunhofer ENAS, who also working on MUT technologies.

One special feature of the ultrasonic transducers from Fraunhofer ENAS is that they can be operated capacitively or piezoelectrically. The difference lies in their structure, which typically consists of two electrodes. In capacitive micromachined ultrasonic transducers (CMUTs), an electrostatic force is created between the two electrodes. When an electric current is applied, an electric field is created, starting the membrane to vibrate and generate sound waves. In piezoelectric micromachined ultrasonic transducers (PMUTs), by contrast, piezoelectric thin films are applied directly to the membrane. These piezoelectric materials convert the electrical signals generated when current is applied into mechanical deflection, thereby causing the membrane to vibrate directly and generating ultrasonic waves.

© Fraunhofer ENAS
Example of a piezoelectric micromachined ultrasonic transducer featuring more than 4,000 membranes and six channels for electrical stimulation on a chip just 10 x 10 square millimeters in size.
© Wojciech-P/Getty Images Pro/Canva
MUT technologies also show their strengths underwater, for example in the field of navigation for divers.
© Damocean/Getty Images/Canva
But MUT technologies are also suitable for mapping underwater topography.

Flexible in every way: high levels of design freedom and a wide range of applications

“Whichever ultrasonic transducer our customers choose, there’s one thing they can always count on: Our transducers can adapt flexibly to a broad spectrum of customer wishes and be produced in various configurations,” Chris Stöckel explains.

They typically consist of many ultrasound cells, which can be connected in parallel or arranged in arrays made up of multiple separately controllable elements. Depending on their shape, size and number, the membranes can be placed on chips of widely varying sizes. Lithography makes it possible to produce components with ultra-tiny dimensions, so there are practically no limits to the extent of miniaturization that is possible.

But individual configuration is not the only thing that makes the ultrasonic transducers flexible. They are also highly versatile in terms of the areas where they can be used: In addition to medicine, where ultrasonic transducers are used to diagnose disease and in obstetrics to monitor fetal development and the course of pregnancy, they are also ideal for uses in materials science and analysis. Because they permit nondestructive testing of internal structures, they can be used in inspection and quality control to reliably detect flaws in materials, such as cracks or other defects that significantly restrict functionality. This makes them interesting for the automotive industry, industrial manufacturing, the construction trade and the aerospace industry as well as for mobility in rail transportation. Beyond that, ultrasonic transducers can also be used in the energy sector: Their ability to measure the concentration of gases makes them ideal for checking the tiniest changes in the amount of hydrogen present in fuel cells, where it interacts with oxygen to generate electricity.

Their unique advantages, such as miniaturization, high sensitivity, temperature stability, design flexibility and the possibility of realizing multiple frequency ranges, make the ultrasonic transducers not only of interest for use in the energy sector but also for other industrial areas, such as the chemicals industry, where they can be used for things like flow measurement and measuring fill levels at high temperature.

There are also advantages for applications under water in identifying objects and mapping topography. The detailed acoustic images of underwater objects that MUTs produce can be used for activities such as surveying the ocean floor, helping divers to navigate, monitoring critical underwater infrastructure and revealing secrets that lie beneath the surface in underwater archaeology.

© Fraunhofer ENAS
Optically transparent capacitive micromachined ultrasonic transducers on a 6” wafer that enable illumination through the transducer for compact photoacoustic imaging.
© Fraunhofer ENAS
The micromechanical ultrasonic transducers are suitable for use in medical diagnostics as well as for industrial applications.

Optics and sound combined: Light and sound together provide more detailed information for industry and medicine

“But ultrasound technologies also have their limits, namely when a diagnostic scan involves evaluating tissue with high water content, for example. They reach their limits fairly soon in those cases. Since liquids do not reflect ultrasonic waves but instead let them pass through almost unimpeded, the tissue appears in barely distinguishable shades of gray in the image. Ultrasound also doesn’t provide any information on the biological parameters of the tissue, like its molecular composition or morphology. That makes it challenging to establish solid findings,” explains Dr. Mario Baum, head of the “Health Systems” department at Fraunhofer ENAS.

A new type of imaging known as photoacoustics (also optoacoustics) has been developed to address this. In this method, the tissue is stimulated not acoustically with ultrasound but optically with light. Pulsed laser light is beamed at tissue or materials, causing local warming and expansion and, in turn, an acoustic wave. The ultrasonic transducer, acting as a receiver, can convert this acoustic signal into electrical signals and measure it.

“One especially interesting aspect is that laser light of different wavelengths can be used to selectively stimulate different types of tissue, so scans can concentrate on specific areas. For example, blood vessels or tumorous cell tissue can be made specifically and clearly visible,” Mario Baum explains.

This means optoacoustics not only significantly improves resolution but also increases the level of detail in the images. In this way, physicians can get further information about the composition and structure of the tissue or material, enhancing diagnostic certainty.

Everything from a single source: ultrasound expertise from Fraunhofer ENAS

Fraunhofer ENAS specializes in developing and producing micromachined ultrasonic transducers. The institute in Chemnitz is a one-stop shop for everything customers may need in this segment, from the initial idea to the design of ultrasonic transducers, structuring of silicon wafers, development of electronics for measurement and analysis, thoughtful packaging concepts to protect the ultrasonic transducers in the environments where they will be used and beyond to integrating the transducers into complex system solutions.

Ultrasonic transducers from Fraunhofer are impressive for a variety of factors:

  • Outstanding sensitivity
  • Great design freedom with high individualizability
  • High level of miniaturization
  • Exceptional stability, including in high-temperature and harsh environments (tested at >200 °C)
  • Nontoxic materials (RoHS conformity)
  • Production of large unit volumes with great reproducibility
  • Plug-and-play solutions that are ready to use right away, without laborious and time-consuming configuration or installation

If you would like to join the many satisfied customers already benefiting from these advantages and use the latest generation of ultrasound technologies to unlock fascinating insights with the utmost levels of detail, contact us today!

We even offer a fully functional evaluation kit you can use to test your use cases. Feel free to get in touch.

 

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